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    • 专利摘要:
    SHEET CONTAINING SUBSTANCES TO INACTIVATE VIRUSES; SHEET, PROTECTIVE CLOTHING, GLOVE, FABRIC FOR MEDICAL USE, COVER, SHOE PROTECTOR, FILTER, SURGICAL TAPE, GAZE AND 5 WALL PAPER USING THE SHEET.It was revealed a leaf containing substances to inactivate viruses that can - inactivate viruses adhering to that leaf regardless of the existence of an envelope, or the presence of lipids or proteins. The leaf containing substances «to inactivate viruses can inactivate the virus by adhering to it, and is characterized by having a leaf body, and microparticles of univalent copper derivatives and / or iodide microparticles retained in the leaf body. The leaf containing substances to inactivate viruses can inactivate a variety of viruses and can inactivate said viruses even in the presence of lipids and proteins.
    公开号:BR112012007032A2
    申请号:R112012007032-0
    申请日:2010-10-04
    公开日:2020-08-11
    发明作者:Yoshie Fujimori；Youhei Jikihara；Tetsuya Sato；Yoko Fukui
    申请人:Nbc Meshtec, Inc.；
    IPC主号:
    专利说明:

    "SHEET CONTAINING SUBSTANCES TO INACTIVATE VIRUSES; SHEET, PROTECTIVE CLOTHING, GLOVE, MEDICAL USE FABRIC, COVER, SHOE PROTECTOR, FILTER, SURGICAL TAPE, GAZE AND WALLPAPER USING THE FOLLOWED SHEET" 5 The present invention refers to a leaf containing substances to inactivate viruses.
    In particular, the invention relates to a sheet containing substances for
    - inactivate viruses that can inactivate various viruses by adhering to it, even in the presence of lipids and proteins regardless of whether the virus has an rr envelope or not. 10 STATE OF THE TECHNIQUE In recent years, deaths from viral infections, such as SARS (severe acute respiratory syndrome), norovirus, and avian influenza, have been reported.
    Currently, due to developments in virus transmission and mutation, the world faces the risk of a "pandemic" which is an epidemic of viral infection worldwide, and there is an urgent need for countermeasures.
    To address this situation, the development of vaccines based on antiviral drugs is accelerating.
    However, since vaccines have their own specificity, they can only prevent infections with specific viruses.
    In hospitals and clinics, nosocomial infection is a serious problem
    20 and this is also being recognized as a social problem.
    Nosocomial infection is a contagious infection with MRSA bacteria (Staphy / ococcus aureus resistant to methicillin) taken to a hospital by a carrier, by an infected person or by the NIRS family Staphylococcus aureus is caused by the use of antibiotics.
    This contagious infection occurs from a patient directly to other patients and health professionals or through articles used by health professionals, such as white scrubs, surgical pajamas, and medical sheets, or an environment including walls and facilities. air conditioning.
    Therefore, there is a strong demand for the development of an antiviral member capable of exhibiting bactericidal and 30 antiviral effects for various viruses and bacteria.
    As a means of solving the preceding problems, there is a sheet containing substances to inactivate viruses that uses a body composed of a resin containing within it porous inorganic crystals that support the antibacterial metal ions, such as silver ions or copper ions ( Patent Literature 1). Virus inactivating agents containing dissolved cytodextrin clathrate iodide derivatives have been reported (Patent Literature 2, 3 and 4). Citation List 5 Patent Literature Patent Literature 1: Japanese Patent Application No. 2006- - 291031. Patent Literature 2: Japanese Patent Application No. 2006-. 328039. 10 Patent Literature 3: Japanese Patent Application Disclosure No. 2007-39395. Patent Literature 4: Japanese Patent Application Disclosure No. 2007-
    39396. Invention Summary Technical Problem 15 The method that uses a resin containing porous inorganic crystals is applied to fibrous nonwovens. However, this method is not applied to non-fiber peels and sheets and inorganic materials. The virus inactivating agent that uses iodide is soluble in water. Therefore, when a nonwoven or sheet is impregnated with said virus inactivating agent, if the nonwoven or sheet is moistened with water, the components of the same will be easily dissolved in water. Viruses can be classified among those without envelopes, such as norovirus, and those with envelopes, such as influenza viruses. 25 Although a drug can inactivate viruses with envelopes, this drug may not be effective for viruses that do not have envelopes. When an inactivation sheet is applied to a mask or used for, for example, surgical protective clothing or pillowcases, the liplets and protein contained in body fluids, such as blood and saliva, can adhere to the inactivation sheet because it is an article used in contact with the mouth or nose of an infected person. Therefore, it is preferable that viruses can be inactivated even in an environment in which lipids and proteins are present. However, this is not observed in the above literature.
    d Y 3/41 To solve the preceding problems, the present invention provides a sheet containing substances to inactivate viruses that can inactivate viruses adhering to it even in the presence of lipids and proteases regardless of whether the virus has envelopes or not. 5 Solution to the Problem A first aspect of the invention is a leaf containing substances · to inactivate viruses that can inactivate a virus adhering to it, the leaf containing substances to inactivate viruses characterized by comprising a
    F sheet body and small particles of monovalent copper derivatives and / or 10 small particles of iodide, the small particles of monovalent copper derivatives and / or small particles of iodide being retained by the sheet body. In the present description, the leaf containing substances to inactivate viruses means a leaf having an ability to inactivate viruses (to reduce virus contamination or to deactivate the virus). Therefore, the concept of leaf 15 containing substances to inactivate viruses includes in addition to the leaf body used for the purpose of inactivating the virus, sheets of wallpaper used for decoration and other purposes, and so on. In the present description, the virus inactivating capacity and the antiviral capacity are used in the same direction. A second aspect of the present invention is the sheet containing substances to inactivate viruses according to the first aspect, characterized in that the small particles of monovalent copper derivatives are particles selected from at least one group consisting of a chloride, an acetate, a sulfide, an iodide, a bromide, a peroxide, an oxide, and a thiocyanate. A third aspect of the invention is the leaf containing substances to inactivate viruses according to the second aspect, characterized in that the small particles of monovalent copper derivatives are particles selected from at least one group consisting of CuCl, CuOOCCH3, Cul, Cu8r , Cu2O, Cu, S, and CuSCN. A fourth aspect of the invention is the sheet containing substances to inactivate viruses according to any aspect from the first to the third aspects, characterized in that the small particles of iodide are particles selected from at least one group consisting of Cul, Agl, Sbh, lrl ,,
    f ¶ 4/41
    Ge | 2, Ge | 4, Sn | 2, Snk, Tll, Ptk, Pd] 2, Bi | 3, Aul, Auh, Fe | 2, Co | 2, Ni | 2, Zn | 2, Hgl, and Inl > A fifth aspect of the invention is the sheet containing substances to inactivate viruses according to any one of the first to fourth aspects, characterized in that the small particles of monovalent copper derivatives and / or small particles of iodide are retained
    - by the sheet body through a group or other small inorganic particles that are retained to this sheet body by means of chemical bonds with a silane monomer and / or a polymerization product of the silane monomer.
    A sixth aspect of the invention is a sheet that uses the sheet containing substances to inactivate viruses according to any aspect of the first to the fifth.
    A seventh aspect of the invention is protective clothing that uses the leaf containing substances to inactivate viruses according to any aspect from the first to the fifth.
    An eighth aspect of the invention is a glove that uses the sheet containing substances to inactivate viruses according to any aspect of the first through the fifth.
    A ninth aspect of the invention is a tissue for medical use that uses sheet 20 containing substances to inactivate viruses according to any aspect of the first to the fifth.
    A tenth aspect of the invention is a cover that uses the sheet containing substances to inactivate viruses according to any aspect from the first to the fifth. An eleventh aspect of the invention is a shoe protection that uses the sheet containing substances to inactivate viruses according to any aspect of the first to the fifth.
    A twelfth aspect of the invention is a filter that uses the leaf containing substances to inactivate viruses according to any aspect of the first through the fifth.
    A thirteenth aspect of the invention is a surgical tape that uses the sheet containing substances to inactivate viruses according to any aspect of the first to the fifth.
    A fourteenth aspect of the invention is a gauze that uses the sheet containing substances to inactivate viruses according to any aspect of the first to the fifth. A fifteenth aspect of the invention is a wallpaper that uses sheet 5 containing substances to inactivate viruses according to any aspect of the first to fifth.
    Advantageous effects of the invention The present invention can provide a leaf containing substances to inactivate viruses that can inactivate the virus, for example, adhering to the surface of leaf 10 even in the presence of stem cells, such as droplets and blood. Brief Description of the Drawings Figure 1 is a graphic representation of a section cut from a leaf containing substances to inactivate viruses from a first configuration. Figure 2 is a graphical representation of a section cut from a leaf 15 containing substances to inactivate viruses of a second configuration. Figure 3 is a graphic representation of a section cut from a leaf containing substances to inactivate viruses of a third configuration. Description of Configurations A first configuration will be described specifically with reference to Figure 1. Figure 1 is a representation of an enlarged view of a cut-out part of a sheet containing substances to inactivate virus 100 from the first configuration of the present invention. Small inorganic particles 2 having the ability to inactivate the virus (treated here as small particles of virus inactivation) are attached to the surface of a leaf body 1 used as a substrate by, for example, a binder. In the first configuration of the present invention, a silane monomer or an oligomer obtained by polymerizing the silane monomer is used as the binder for reasons that will be described later. Therefore, in the example shown in the graphical representation in Figure 1, in order to facilitate understanding, the small virus inactivating particles 2 are connected to the surface of the leaf body 1 through chemical bonds 5 by means of a silane monomer. (or a polymerized silane monomer product) 3. Here, a dimer is exemplified as the oligomer. In the present configuration, a reinforcement material 4 is used to firmly attach the small virus inactivation particles 2 to the sheet body 1, as shown in Figure 1. Reinforcement material 4 is added when necessary to firmly secure the small 5 particles virus 2 inactivation to leaf body 1 and is not necessarily added.
    - In the first configuration, the small virus 2 inactivation particles are small particles of monovalent copper derivatives and / or small particles of iodide and can inactivate the virus regardless of whether or not these 10 have the envelope. Therefore, the sheet containing substances to inactivate virus 100 of the first configuration can be considered to retain an antiviral agent including at least one type of small inorganic particles selected from a group consisting of small particles of monovalent copper derivatives and / or small particles of iodide. The 15 small virus 2 inactivating particles of the first configuration can inactivate the viruses even in the presence of proteins and liplets. Currently, the mechanism of virus inactivation of the small particles of virus inactivation 2 is not clear. The mechanism should be as follows. When small virus 2 inactivation particles come into contact with moisture in the air or in droplets, part of the small virus 2 inactivation particles undergo an oxidation reduction reaction, or active species are produced. This causes some effect on the electrical charge on the surface or on the DNA of the virus that adheres to the leaf containing substances to inactivate viruses 100 of the first configuration, and the viruses are thus inactivated. There is no particular imposition of a limit on the size of the retention of the small particles of virus 2 inactivation, and a person skilled in the art can adjust the size accordingly. However, the average particle diameter is lnm or greater and less than 500 µm, preferably 30 lnm or greater and less than 1 µm, and more preferably 1 nm or greater and less than 500 nm. When the average particle diameter is less than 1 nm, the small virus 2 inactivating particles will be physically unstable and will clump together. Therefore, it will be difficult to sustain the m particles on the sheet body 1 evenly. When the average particle diameter is 500 µm or greater, the adhesion between the particles and the sheet body 1 will be less than when the average particle diameter decreases within the above range. In the present description, the average particle diameter is an average diameter of the volume particle. There is no particular imposition of a limit on the type of small virus inactivation 2 particles serving as an active ingredient. However, small particles of monovalent copper derivatives are preferably particles of a chloride, an acetate (an acetate derivative), a sulfide, an iodide, a bromide, a peroxide, an oxide, a thiocyanate, or a mixture of the same. More preferably, the small particles of monovalent copper derivatives are selected particles from at least one group consisting of CuCl, CuOOCCH ,, Cul, Cu8r, Cu2O, Cu, S, and CuSCN. Preferably, the small iodide particles are selected particles 15 from at least one group consisting of Cul, Agl, Sbb, | r | 4, Gel2, Ge | 4, Sn | 2, Snl ,, Tll, Pt | 4, Pd | 2, Bil ,,, Aul, Aul ,,, Fe | 2, Co | 2, Ni | 2, Znl2, Hgl, and lnb. More specifically, in the first configuration, only one type of particle can be used as the small virus inactivation particles retained 2, or two or more types of particles can be retained by the leaf body 1. 20 In the first configuration, the small particles of virus inactivation 2 are attached to the leaf body 1 via a ligand. As described above, in Figure 1, the silane monomer (or a polymerization product thereof) 3 is shown as the binder used. However, it is not limited to this, and any known binder can be used. There is no imposition of a particular limit 25 on the binder as long as it has, for example, high adhesion to the sheet body
    1. Examples of binders used include: synthetic resins, such as polyester resins, amino resins, epoxy resins, polyurethane resins, acrylic resins, water-soluble resins, vinyl-based resins, Huoride resins, silicone, cellulose-based resins, phenolic resins, 30 xylene resins, and toluene resins; and natural resins, such as dry oils, for example castor oil, linseed oil, tung oil. In the present configuration, silane monomer 3 or an oligomer obtained by polymerizing the silane monomer are used as the binder,
    0 r 8/41 as described above. This is because, since the molecular weight of these monomer and oligomer are low, the monomer or oligomer does not fully cover the small particles of virus 2 inactivation, and the contact between the small particles of virus 2 inactivation with the virus adhering to the virus. 5-leaf body 1 is less likely to be avoided. Therefore, the use of silane monomer (or a polymerization product of the same) 3 as the ligand allows effective virus inactivation. Since the bonds provided by the silane monomer 3 are firm, adhesion to the sheet body 1 is improved and small
    K virus inactivation particles 2 can be more stably supported 10 on the leaf body 1. Specific examples of the silane monomer used for the leaf containing substances to inactivate virus 100 of the first configuration include silane monomers represented by a general formula X -Si (OR) n (n is an integer from 1 to 3); X is a functional group that reacts with an organic material, and 15 examples of it include a vinyl group, an epoxy group, a styryl group, a methacryl group, an acryloxy group, an isocyanate group, a polysulfide group, an amino group, a mercapto group, and a chlorine group; each OR is a hydrolyzable alkoxy group, such as a methoxy group or an ethoxy group and the three functional groups on the silane monomer can be the same or different. These 20 alkoxy groups including the methoxy and ethoxy groups are hydrolyzed to form silanol groups. The reactivity of said silanol group, vinyl group, epoxy group, styrene group, methacryl group, acryloxy group, isocyanate group, and functional groups having an unsaturated bond and the like must be high. More specifically, in the sheet containing substances to inactivate virus 100 of the first configuration, the small virus inactivation particles 2 are firmly retained on the surface of the leaf body 1 by means of chemical bonds 5 through the silane monomer having high reactivity. Examples of silane monomer represented by the general formula above include vinyl-trichlorosilane, vinyl-trimethoxysilane, vinyl-triethoxysilane, vinyl-triacetoxy-silane, NB- (N-vini | -benzi | -aminoethi |) -y-aminopropyl -trimetoxisi | ano, a hydrochloride of N- (vini | -benzi |) -2-aminoethi | -3-aminopropi | -trimetoxisi | ano, 2- (3,4 epoxy-cyclohexyl) ethyltrimethoxysilane, 3-glycidoxy-propyl- trimethoxisan, 3-glycidoxy-propyl-trimethoxysilane, 3-glycidoxy-propyl-methylpiethoxyl, 3-glycidoxy-propyl-
    triethoxysilane, p-styryl-trimethoxysilane, 3-methacryloxy-propyl-metikdimethoxysilane, 3-methacryloxy-propyl-trimethoxysilane, 3-methacryl | oxj-propjl-meti | -dietoxypropyl, 3-methacryloxypropi-triethoxy trimethoxysilane, propyl-triethoxysilane 3-isocyanate, bis (triethoxy-silyl-propyl) tetrasulfide, 3-aminopropyl-5 trimethoxysilane, 3-aminoprol i1-triethoxysilane, 3-triethoxysilyl-N- (1,3-dimethyl-butylidene) ) propylamine, N-phenyl-3-aminopropiktrimethoxyshan, N-2- (aminoethyl) -3-aminopropyl- - methyl | -dimethoxis | year, N-2- (aminoethyl |) -3-aminopropyl-trimethoxysilane, N-2- (aminoethyl) -3-aminopropyl-triethoxysilane, 3-mercaptopropyl-methyl-dimethoxy silane, 3-. mercaptopropi | -trimetoxisi | ano, N-pheni | -3-aminopropi | -trimetoxisi | ano, special 10-aminosilanes, 3-ureidopropi | -trjetoxisi | ano, 3-c | oropropyl-trimetoxisi | ano, silane tetramethoxy, tetraethoxysilane, methyl -trimethoxysilane, methyl-triethoxysilane, dimethyl-diethoxysilane, phenyl-triethoxysilane, hexamethyldisilazane, hexyl-trimethoxysilane, decj | trimethoxysilane, hydrolyzable groups containing siloxanes, oligomers containing fluoroalkyl, methyl-hydrogen and siloxane.
    15 Examples of silane-based oligomers include the commercially available oligomers KC-89S, KR-500, X-40-9225, KR-217, KR-9218, KR-213, and KR-510, which are all products of Shin-Etsu Chemical Co., Ltd. These silane-based oligomers can be used alone, as a mixture of two or more of the same, or as a mixture of two or more of the same, or as a mixture with one or two or more of the silane monomers described above. As described above, in the sheet containing substances to inactivate virus 100 of the first configuration, the small virus inactivation particles 2 are retained by the leaf body 1 through the silane monomer or oligomer thereof with at least part of its surfaces being exposed. Therefore, the probability of contact of the virus and bacteria adhering to the leaf surface containing substances to inactivate virus 100 with the small virus 2 inactivation particles may be greater than that when the small virus 2 inactivation particles are attached to the virus. sheet body 1 using a generative binder such as a resin. Therefore, the virus can be effectively inactivated even using a small amount of small virus inactivating particles 2.> Since the small virus inactivating particles 2 are firmly attached to the leaf body 1 by means of chemical bonds 5 with the d 7 10/41 silane monomer or oligomer of the same 3, the amount of small virus inactivating particles 2 that detach from the leaf body 1 is significantly reduced when compared to that amount when the particles are coated and fixed with, for example, a general binder component such as a resin.
    Therefore, the sheet containing substances to inactivate virus 100 from the first configuration can maintain its virus inactivation effect for a
    - long period.
    The small virus inactivation particles 2 can be retained not by chemical bonds 5 but by a condensation reaction, * starch bridges, hydrogen bridges, Ion bridges, 10 van der Waals forces, or physical absorption. This can be achieved by selecting a suitable silane monomer to be used.
    In this first configuration, there is no particular imposition of a limit on the form of retaining the small "virus inactivation particles 2 through the leaf body 1 and the shape can be appropriately selected by a person skilled in the art.
    For example, the small virus 2 inactivation particles can be moved around the leaf body 1. The small virus 2 inactivation particles can be retained as small, inorganic, grouped particles arranged in double or three dimensions.
    More specifically, the small virus inactivating particles 2 can be retained, for example, in the form of a dot, elevations or thin film.
    When the small virus 2 inactivation particles are retained as grouped three-dimensionally, they include particles attached to the leaf body 1 by means of the silane monomer or oligomer thereof 3 (these particles are referred to as small virus inactivation particles 2a) and particles. 25 connected to the leaf body 1 by means of at least small particles of virus inactivation 2a.
    Preferably, the small virus inactivating particles 2 are retained in the leaf body 1 as grouped three-dimensionally because a large number of small irregularities are formed on the surface of the leaf body 30 and the adhesion of dust and the like to the body of sheet 1 is suspended due to irregularities.
    Suspending the adhesion of the powder and the like allows the effect of inactivating the leaf virus containing substances to inactivate virus 100 to be maintained for a long period.
    0; 11/41
    In the sheet containing substances to inactivate virus 100 of the first configuration, a functional material is optionally used, in addition to the small particles of virus inactivation 2, to provide a desired function for the sheet containing substances to inactivate virus 100. This functional material can be retained about 5 the surface of the leaf body 1. Examples of the functional material include other antiviral agents, antimicrobial agents, antifungal agents, agents
    - antiallergic, and catalltics.
    Said functional material can be attached to the leaf body 1, to the small virus inactivating particles 2, and so on 0, for example, by means of a general binder.
    As for the small particles of virus 2 inactivation, the functional material must be retained in the leaf body 1, by means of, for example, chemical bonds between the surface of the leaf body 1 and the silane monomer or oligomer of the same 3 bonded to the surface of the functional material. Regardless of whether the functional material except the small virus inactivating particles 2 is or is not retained in the leaf body 1, the 15 small virus inactivating particles 2 can be attached to the leaf body 1 by an additional reinforcing agent (agent coating) 4 in addition to the silane monomer or oligomer thereof 3, as shown in Figure 1. In the following description, the materials retained by the sheet body 1 (these materials stain the small virus inactivation particles 2, the monomer 20 of silane 3 (or oligomer thereof 3), and so on) are referred to as a sheet-retained composition.
    A person skilled in the art can appropriately adjust the amount of small virus inactivation particles 2 retained by the leaf containing substances to inactivate virus 100 of the first configuration, 25 considering the purpose of using and applying the leaf containing substances to inactivate virus 100 and the size of the small particles.
    The amount of small virus 2 inactivation particles in the sheet-retained composition is preferably 0.1 ° 6 by mass to 80.0 ° 6 by mass and more preferably 0.1 ° 6 by mass at 60 ° 0 by mass.
    When the amount of small virus 2 inactivation particles is less than 0.1 ° 6 per mass, the effect of inactivating the leaf virus containing substances to inactivate virus 100 will be less than when the amount decreases within the above range.
    When the amount is greater than 80.0% by mass, the effect of inactivating the leaf virus containing substances to inactivate 100 µM will not be much different than when the amount decreases within the above range.
    Furthermore, the binding properties (the ability to retain) of the oligomer formed by the condensation reaction of the silane monomer are reduced, and therefore, the small virus inactivating particles 2 detach from the leaf body 1 more easily than that when the quantity decreases within the
    · Above range.
    A description will be given later of the leaf body 1 on which the 'small virus inactivation particles 2 are retained.
    Any 10-leaf body can be used as the leaf body 1 on the leaf containing substances to inactivate virus 100 of the first configuration, provided that the leaf body 1 can be chemically linked to the silane monomer or oligomer of the same 3 in at least part of the sheet body surface 1. Therefore, in the first configuration, no particular limits are imposed on the other properties 15 of the sheet body.
    There is no particular limit imposed on the shape of the leaf body 1, as long as it has a leaf shape.
    Examples of the sheet body 1 having a surface in which the silane monomer or oligomer thereof 3 can be chemically bonded includes a sheet body 1 having a surface that is at least partially composed of any of several resins, 20 synthetic fibers, natural fibers, such as cotton, hemp, and silk, and Japanese paper obtained from natural fibers.
    When the surface or entire part of the sheet body 1 is formed of a resin, a synthetic resin or a natural resin is used.
    Examples of such resins include thermoplastic resins, such as polyethylene resins, polypropylene resins, polystyrene resins, ABS resins, AS resins, EVA resins, polymethylpentane resins, polyvinyl chloride resins, polymethylmethacrylate resins, polyvinyl acetate resins , polyamide resins, polyimide resins, polycarbonate resins, polyethylene terephthalate resins, polybutylene terephthalate resins, polyacetal resins, polyarylate resins, 30 polysulfone resins, polyvinylidene fluoride resins, Vectran® (registered trademark), and PTFE (polytetrafluoroethylene); biodegradable resins, such as polylactic resins, polyhydroxybutyrate resins, modified starch resins, polycaprolactone resins, polybutylene succinate resins,
    H T 13/41 polybutylene adipate terephthalate, polybutylene succinate terephthalate resins, and polyethylene succinate resins; thermosetting resins, such as phenolic resins, urea resins, melamine resins, unsaturated polyester resins, dialysis phthalate resins, epoxy resins, epoxy acrylate resins, silicone resins, 5 acrylic urethane resins, and urethane resins; elastomers, such as silicone resins, polystyrene elastomers, polyethylene elastomers, polypropylene elastomers, and polyurethane elastomers; and natural resins, such as varnish.
    In the first configuration, the surface of the sheet body 1 can be formed of any of the metal materials, such as aluminum, stainless steel, and iron and inorganic materials, such as glass and ceramics, as long as the chemical bonds 5 with the silane monomer or oligomer thereof 3 can be formed. In this case, as in the case of the resin substrate, for example, the unsaturated bond or reactive functional group 15 of the silane monomer 3 can be reacted with the hydroxy group and so on on the metal surface through the grafting polymerization that will be described subsequently to form the chemical connections 5. In this way, the small virus inactivation particles 2 can be attached to the sheet metal body 1. However, when the functional groups that can form 20 chemical bonds 5 are introduced to the surface of the body of leaf 1 through a silane monomer, a titanium monomer, and so on, the small virus 2 inactivating particles can be more firmly attached. Examples of the functional group originating from the silane monomer and introduced to the surface of the sheet body 1 include a vinyl group, an epoxy group, a styryl group, a methacryl group, an acryloxy group, an isocyanate group and an thiol. The leaf body 1 of the leaf containing substances to inactivate virus 100 of the first configuration will be described in detail. For example, the sheet body 1 according to the first configuration will be formed of fibers. More specifically, the sheet body 1 can be a sheet of fabric, interwoven fibers, nonwovens and so on. Therefore, the sheet containing substances to inactivate virus 100 of the first configuration can be used to form masks, covers, shoe protectors, air conditioning filters,
    filters for air purifiers, filters for purifiers, filters for fans, filters for vehicles, filters for air conditioners, filters for artificial ventilation, air conditioner (HME), medical clothing (aprons and towels), surgical fabrics, surgical tapes , gauze, wallpaper, clothing, 5 bedding, insecticide nets, cage nets, and other nets, such as mosquito nets. Examples of fibers that make up the sheet body 1 include fibers made from polymer materials, such as, polyester, polyethylene, polypropylene, chloride
    W pdivinyl, ithium terephthalate | iethylene, polybutylene terephthalate, polytetramethylene terephthalate, nylon, acrylic, polytetral1uorethylene, polyvinyl alcohol, kevlar®, polyacrylic acid, polymethylmetacrikto, artificial silk, copper, tincet®, polyethylene, acetate, tincet® , hemp, wool, silk, and bamboo; and metals, such as aluminum, iron, stainless steel, bronze, copper, tungsten, and titanium. An additional member, such as a leaf or leaf, can be stacked 15 on the leaf surface containing substances to inactivate virus 100 from the first configuration. For example, waterproof properties can be transmitted to the sheet containing substances to inactivate virus 100 by stacking a waterproof sheet or sheet. As the sheet containing substances to inactivate viruses 100 pcs has waterproof properties, 20 covers and medical gloves with high-protection performance can be produced and can avoid contamination of the virus with blood, for example, by sewing these tissues with the sheet , and sheets for hospitals and wards can also be produced. A permeable pehcula or leaf that blocks the passage of water, however, 25 allows the passage of air (humidity) is preferably used as the film or leaf that will be stacked so that the user's comfort is guaranteed. More specifically, the pehcula or leaf that will be used can be selected from products available in general trade according to the purpose of use. 30 An adhesive or the like can be stacked on at least one main surface of the sheet containing substances to inactivate viruses 100 of the first configuration so that the user can easily and freely fix the sheet on a mask, a wall, or a floor. More specifically,
    by applying the sheet containing substances to inactivate virus 100 of the first configuration to the surface of an existing mask, a virus inactivation mask can be formed.
    The leaf body 1 of the leaf containing substances to inactivate virus 5 100 of the first configuration is not limited to a body with a breathable structure and may not allow air to pass through,
    - that is, it must have air blocking properties.
    More specifically, the sheet body 1 can be formed into a 0-shaped format using any of the resins, such as, polyester, polyethylene, polyamide, 10 polyvinyl chloride, polyvinylidene fluoride, polyvinyl alcohol, polyvinyl acetate, polyimide, imide polyamide, polyethylene and a copolymer of ethylene tetrafluoroethylene; polymer sheets, such as polycarbonate resin sheets and pellets, vinyl chloride sheets, fluorocarbon resin sheets, polyethylene sheets, silicone resin sheets, nylon sheets, 15 ABS sheets, and urethane sheets ; and metals, such as titanium, aluminum, stainless steel, magnesium, and bronze.
    More preferably, the surface of the sheet body 1 having air blocking properties is hydrophilized in advance for example by corona treatment, atmospheric plasma treatment, or flame treatment to improve the adhesion of the small virus inactivating particles 2 to the body. sheet 1. It is preferable for sheet body 1 formed from a metal that oil and corrosive products adhering to its surface are removed using a solvent, acid, alkali, and so on.
    The surface of the sheet body 1 can be coated or printed. 25 The sheet containing substances to inactivate virus 100 that has air blocking properties and has the small virus 2 inactivation particles retained in it can be used in diverse fields, such as in wallpapers, curtains, blinds, and games. American table place, food storage bags, food packaging seals, keypad protector, touch screens, touch screen protectors, medical clothing, surgical clothing, interior materials for hospitals and other buildings, interior for trains and automobiles, leaves for vehicles, covers for chairs and sofas, facilities for handling viruses, resistant leaves
    [Go to the sun for doors and board floors, masks for breathing apparatus, and parts of breathing apparatus. Reinforcement material 4 is added when the small virus inactivation particles 2 are firmly attached to the leaf body 1, as described above. Any of the several resins exemplified above as the Binder can be used as the reinforcement material 4. A silane monomer except the compound used as the silane monomer 3 can be used as the reinforcement material 4.
    V The method of making the sheet containing substances to inactivate virus 100 of the first configuration which has the small virus 2 inactivation particles retained therein will be described more specifically. First, at least one material is selected from 4 monovalent copper and iodide derivatives. Then, the selected material is sprayed on particles from submicrometers to micrometers using, for example, for milling, the jet mills, hammer mills, ball mill or vibrators to obtain small particles of virus inactivation. There is no imposition of a specific limit on spraying and any of the processes
    Wet or dry B can be used. After that, the small inactivated particles of sprayed virus 2 are dispersed in a dispersion vessel, such as water, methanol, ethanol, MEK (methyl ethyl ketone), acetone, xylene, or toluene. If other materials, such as reinforcement material 4 and functional materials are mixed with the dispersion, these materials are added to the dispersion at this point. Then, a dispersing agent, such as a surfactant is added if necessary, and the resulting mixture is dispersed and sprayed using an apparatus, such as a ball mill, ball mill, sand mill, roller mill, vibrating mill, or a homogenizer. Then, the silane monomer 3 is added to the dispersion to prepare a paste containing the small virus inactivation particles 2 dispersed therein. When the paste is prepared in the manner described above, the diameter of the small virus inactivating particles 2 is reduced, and these particles 2 are arranged on the surface of the leaf body 1 without excessively large gaps formed between the particles 2. The density of the particle of the small particles of virus inactivation 2 can thus be increased, and therefore a high virus inactivation capacity can be achieved.
    The paste prepared as described above is applied to the surface of the sheet body 1 using a technique, such as, a dipping technique, a spraying technique, a roller coating technique, a bar coating technique, a coating technique rotation coating, a technique
    - gravure printing, an offset printing technique, a canvas printing technique, or an inkjet printing technique.
    If necessary, the solvent is removed, for example, by heating and drying and so on.
    Thereafter, the functional groups on the surface of the sheet body 1 are chemically linked to the silane monomer (the formation of the chemical bonds ..7 5) through grafting polymerization by means of reheating or grafting polymerization by irradiation with intra-red rays, ultraviolet rays, cathode rays, radioactive rays, such as y-rays.
    During graft polymerization, the small virus 2 inactivation particles are linked to each other via the silane monomer or the oligomer formed from it 3. After that, if necessary, a film or an adhesive is stacked on the body of sheet 1 using, for example, heating rollers to thereby obtain a sheet containing substances to inactivate virus 100 from the first configuration.
    With the sheet containing substances to inactivate virus 100 described above from the first configuration, different viruses can be inactivated regardless of the types of genome and whether the viruses have envelopes or not.
    Examples of virus 25 include rhinovirus, poliovirus, viruses that cause disease in the mouth and feet, rotavirus, norovirus, enterovirus, hepatovirus, astrovirus, hepatitis E virus, influenza virus type A, B and C, parainfluenza virus, virus mumps virus, measles virus, human virus metapneumus, RS virus, nipah virus, hendra virus, yellow fever virus, dengue virus, Japanese encephalitis virus, West 30 nile virus, hepatitis B virus and C virus, hepatitis B and C virus, C virus equine of the east and west type, o'nyong-nyong virus, rubella virus, lassa virus, junin and machupo virus, guanarite virus, sabiá virus, crimean hemorrhagic fever virus, congo, sandfly fever, hantavirus, hantavirus, hantavirus Navajo flu, rabies virus,
    ebola virus, marburg virus, bat rabies virus, human T-lymphotropic virus, human immunodeficiency virus, human coronavirus, SARS coronavirus, human parvovirus virus, polyoma virus, human papilloma virus, adenovirus, herpesvirus, herpesvirus varicella-zoster virus, EB virus, cytomelovirus, 5 pseudovirus small virus, smallpox virus, bovine smallpox virus, mollusk virus, parapoxvirus.
    · With the leaf containing substances to inactivate virus 100 from the first configuration, the virus can also be inactivated even in the presence of, in addition to
    P of virus, lipids and proteins resulting, for example, from the adhesion of blood or 10 drops. With the sheet containing substances to inactivate virus 100 from the first configuration, the virus adhering to it can be inactivated. Therefore, viral infection through the used leaf can be prevented, and contamination of the virus adhering to the leaf can be stopped, so that the occurrence of a secondary infection 15 can be reduced. A sheet containing substances to inactivate virus 100 from a second configuration will be described below. Figure 2 is a graphical representation of a cutout of the sheet containing substances to inactivate virus 100 of the second configuration. The sheet containing substances to inactivate virus 100 of the second configuration has the same configuration as in the first configuration, k except that in addition to the small inactivation particles of virus 2 (which can be referred to as the first small inorganic particles), the second small inorganic particles 6 are retained in the sheet body 1. In the second configuration, the second small inorganic particles 6 together with the first 25 small inorganic particles 2 form small inorganic particles in which the small inorganic particles are arranged double or three-dimensionally. In other words, in the second configuration, the grouped inorganic particles containing the first small inorganic particles 2 and the second small inorganic particles 6 are retained in the sheet body 1. In Figure 2, a reinforcement material 4 is used to firmly fix the first small inorganic particles 2 and the second small inorganic particles 6 to the sheet body 1. However, as in the first configuration, reinforcement material 4 is not necessarily included.
    Structures common to the first configuration are denoted by the same reference numerals, and the description will be omitted.
    The second small inorganic particles 6 form the chemical bonds 5 with the leaf body 1 through a silane monomer or 5 oligomer thereof 3, and also form the chemical bonds 5 with each other through the silane monomer or oligomer thereof 3. Therefore, in the second configuration, the first small inorganic particles 2 appearing as small virus inactivating particles are retained in the leaf body 1 through the silane monomer or oligomer of the same 3 and through the second small inorganic particles 6 In the second configuration, the first small inorganic particles 2 are retained in the sheet body 1 so as to be interlaced with groups of the second small inorganic particles 6 forming chemical bonds 5 with each other by means of the silane monomer or oligomer thereof 3 15 Therefore, it is prevented that the first small inorganic particles 2 are not released from the leaf body 1 not only through the Connections chemical 5 but also physically.
    In the sheet containing substances to inactivate virus 100 of the second configuration, it is more effectively prevented that the small particles of virus inactivation 2 become detached, when compared to those 20 of the sheet containing substances to inactivate virus 100 of the first configuration.
    Therefore, the ability to inactivate the virus and the disinfectant capacity can be maintained for a long period.
    In the second configuration, the groups of the second small inorganic particles 6 that form the chemical bonds 5 with each other by means of the silane monomer 3 prevent the first small inorganic particles 2 from loosening from the sheet body 1. Therefore, the first small inorganic particles 2 may not form bonds with the second small inorganic particles 6 and the leaf body .1 by means of the silane monomer or oligomer thereof 3. 30 In the leaf containing substances to inactivate virus 100 of the second configuration, the first small inorganic particles 2 serving as the small virus inactivation particles are linked to the second small inorganic particles 6 and to the leaf body 1 through the silane and oligomer monomer thereof, and therefore, the surfaces of the first small particles inorganic 2 are exposed, as in the first configuration.
    Therefore, the probability of contact of the virus adhering to the leaf surface containing substances to inactivate virus 100 with the small particles of inactivation of
    5 virus 2 can be larger than when the small virus inactivation particles 2 are attached to the leaf body 1 using, for example, a general ligand, so that the virus can be effectively inactivated even using a small amount of small particles of virus inactivation 2. 0
    There is no imposition of a particular limit on the second small particles
    10 inorganic 6 according to the second configuration, as long as they can be linked to the silane monomer or oligomer thereof 3, and a person skilled in the art can appropriately select the second small inorganic particles 6. Specifically, non-metallic oxides, metal oxides, oxides derived from metals, nitrides, carbides, silicates, and mixtures
    15 of them can be used.
    The second small inorganic particles 6 can be amorphous or crystalline.
    Examples of non-metallic oxides include silicon oxide.
    Examples of metal oxides include magnesium oxide, barium oxide, barium peroxide, aluminum oxide, tin oxide, titanium oxide, zinc oxide, titanium peroxide, zirconium oxide, iron oxide,
    20 iron hydroxide, tungsten oxide, bismuth oxide, indium oxide, gypsum, bohemite, diaspora, antimony oxide, cobalt oxide, niobium oxide, manganese oxide, nickel oxide, cerium oxide, oxide oxide and praseodymium oxide.
    Examples of metal-derived oxides include titanium-barium oxide, aluminum-cobalt oxide, zirconium oxide, niobium oxide, TiO, -WO3,
    25 A1O, rSiO ,, WO ,, - ZrO ,, WO3-SnO2, CeO, -ZrO2, ln-Sn, Sb-Sn, Sb-Zn, Sb-Zn, ln- Sn-Zn, B2O3-SiO ,, P , O, -SiO ,, TiO2-SiO ,, ZrO, -SiO ,, AI, O ,, - T1O ,, A | 2O3-ZrO2, A | 2O3-CaO, A] 2O3-B2O3, A | 2O3-P2O5 , A | 2O3-CeO2, A | 2O3-Fe2O3, TiO2-ZrO2, TiOr ZrO2-SiO ,, TiO2-ZrO2-A |, O3, TiO2-A | 2O3-SiO2, and TiO2-CeO2-SiO2. Examples of nitrides include titanium nitride, tantalum nitride, and niobium nitride. Examples of carbide include silicon carbide, titanium carbide, and niobium carbide.
    Examples of absorbent silicates include synthetic zeolites, such as, zeolite A, zeolite P, zeolite X and zeolite y; natural zeolites, such as, c | inopti | Ó | itit, sepiólite, and mordenite; derived from the silicate layer, such as,
    kaolinite, montmorillonite, Japanese acid clay and diatomaceous earth; and cyclosilicate derivatives such as wollastonite and neptunite.
    Other examples include phosphate derivatives, such as, tricalcium phosphate, hydrogen calcium phosphate, calcium pyrophosphate, calcium metaphosphate, and hydroxyapatite, activated carbon, porous glasses.
    A specialist in the state of the art can appropriately
    . adjust the diameter of the second small inorganic particle 6, according, for example, for the purpose of using and applying the sheet and the diameter of the first small inorganic particles 2. 10 In consideration of the bond strength to the sheet body 1, the diameter of the second small inorganic particle 6 is preferably 500 nm or less or more preferably 300 nm or less.
    As described above, a person skilled in the art can appropriately adjust the diameter of the second small inorganic particles 6. 15 However, when the diameter is less than 1 nm, the particles will be physically unstable and will coagulate with each other, as in the case of the first small inorganic particles 2, and it will be difficult to sustain the particles in the sheet body 1 evenly.
    Therefore, the diameter is preferably 1 nm or greater. The method of making the sheet containing substances to inactivate virus 100 of the second configuration which has the first small inorganic particles 2 retained therein will be described more specifically later.
    First, as in the first configuration, at least one material is selected from iodides and monovalent copper derivatives.
    Then, the selected material 25 is sprayed onto micrometer particles using, for example, a jet mill, hammer mill, ball mill or vibrating mill to obtain small particles of virus 2 inactivation (first small inorganic particles 2) . There is no imposition of a particular limit on spraying, and any of the wet or dry processes can be used.
    After that, the small inactivated particles of sprayed viruses 2 are mixed with the second small inorganic particles 6 to which the silane monomer 3 has been joined by condensation by dehydration, and the mixture is dispersed in a dispersion vessel, such as , water, methanol, ethanol, MEK, acetone, xylene or toluene. If, in addition to the small virus inactivation particles 2 and the second inorganic particles 6 to which the silane monomer 6 has been joined, other materials, such as reinforcement material 4 and functional materials are mixed with the dispersion, these materials will be added to the dispersion at this point. Then, a dispersing agent, such as a surfactant is added if necessary, and the resulting mixture is dispersed and sprayed using an apparatus, such as a mill.
    Ball w, ball mill, sand mill, roller mill, vibrating mill 10, or a homogenizer to prepare the paste containing the small particles of virus inactivation 2 and the second small inorganic particles 6 dispersed therein. When the paste is prepared in the manner described above, the diameters of the small virus inactivation particles 2 and the second small inorganic particles 6 are reduced, and the first 15 small virus inactivation particles 2 and the second small inorganic particles 6 are arranged on the surface of the leaf body 1 without excessively large gaps formed between particles 2 and 6. The density of the small virus inactivation particles 2 can then be increased, and the groups of the second small inorganic particles 6 can be further firmly fixed to the surface of the leaf body 1. Therefore, a high virus inactivation capacity and a high disinfectant capacity can be achieved, and the virus inactivation capacity and disinfectant capacity can be maintained for a long period. The chemical bonds between the second small inorganic particles 6 and the silane monomer 25 can be formed by an effective method. In an example method, silane monomer 3 is added to a dispersion of the second small inorganic particle 6, and the resulting dispersion is heated under reflux to allow silane monomer 3 to be bonded to the surfaces of particles 6 through a reaction condensation by dehydration to form thin films made of silane monomer 3 in this way. In another example method, silane monomer 3 is added to a dispersion of the second small inorganic particle 6 that has been sprayed to reduce the size of the particles, or alternatively, the silane monomer 3 is added to a dispersion of the second small inorganic particle 6 and the resulting dispersion is sprayed to reduce the size of the particles.
    Then, the solid and liquid are separated from the dispersion including the silane monomer 3, and the separated solid is heated from 100 ° C to 5 180 ° C to allow the silane monomer to be bonded to the surfaces of the second small inorganic particle. 6 through a condensation reaction by
    . dehydration.
    The resulting particles are pulverized and then redispersed.
    In the methods described above, the amount of silane monomer 3 that will be added to the dispersion depends on the average particle diameter and the material of the second small inorganic particle 6. However, when the amount is 3 ° 6 by mass at 30 ° 6 per mass based on the mass of the second small inorganic particles 6, the mutual bond strength between the second small inorganic particles 6 and the bond strength between the groups of the second small inorganic particles 6 and the sheet body 1 constituting the 15 sheet containing substances to inactivate viruses 100 of the present invention do not cause any practical problem.
    Even after the silane monomer 3 and so on are joined to the first small inorganic particles 2 and to the second small inorganic particles 6, the surfaces of the first small inorganic particles 2 will be sufficiently exposed.
    In addition, an excess of silane monomer that is not involved in the bond may be present.
    The description of the method of making the leaf containing substances to inactivate viruses 100 'of the second configuration will be continued.
    As in the first configuration, the paste prepared above is applied to the surface of the body of sheet 25 using a technique, such as an immersion technique, a spraying technique, a roller coating technique, a bar coating technique, a rotation coating technique, an engraving printing technique, an offset printing technique, a canvas printing technique, or an inkjet printing technique.
    If necessary, the solvent is removed by heating and drying and so on.
    Thereafter, the functional groups on the surface of the sheet body 1 are chemically joined, by grafting by grafting by reheating or by grafting polymerization by irradiation with infrared rays, ultraviolet rays, cathode rays, or
    U 0 24/41! radioactive rays, such as y-rays, for the silane monomer 3 attached to the surfaces of the second small inorganic particle 6 which faces the surface of the sheet body 1 (the formation of chemical bonds 5). At the same time, the silane monomers 3 on the surfaces of the second small inorganic particle 6 are chemically bonded together to form an oligomer. At the same time, the small virus inactivation particles 2. are joined to the second small inorganic particles 6 via the silane monomer 3. If an additional silane monomer is used as the
    W reinforcement material 4 is added to obtain firmer bonds between the second small inorganic particle 6 and the leaf body 1, the small virus inactivating particles 2 will be joined to the second small inorganic particles 6 and the leaf body 1 through of the additional silane monomer added as reinforcement material 4 and the oligomer 3 resulting from the silane monomer 3, By means of the above process, the small particles of J5 virus inactivation 2 (the first small inorganic particles 2) having a capacity of virus inactivation are surrounded by groups of the second small inorganic particles 6 and retained by the leaf body 1. If necessary, after the leaf body 1 having the small virus inactivation particles 2 retained on the surface of it is obtained as described above, a pellcuk 20 or an adhesive will be stacked in the same way as in the first configuration to obtain the sheet containing substances to inactivate virus 100 from second configuration. In the above description, silane monomer 3 is bonded to the second small inorganic particles 6 in advance, but this mode 25 is not limited. The small particles of virus inactivation 2, the second small inorganic particles 6 to which no silane monomer has been joined, and the silane monomer 3 can be dispersed in an i] | dispersion container. A person skilled in the art can appropriately adjust the amount of silane monomer 3 added.
    Ç 30 As in the description above, the amount added can be, for example, from 3 ° 6 by mass to 30% by mass based on the mass of the second small, inorganic particles 6. In addition to the above rate, the mutual bond strength between the second small inorganic particles 6 and the bond strength f)) «
    K "25/41 b 'between the groups of the second small inorganic particles 6 and the sheet body 1 do not cause any practical problems. Even after the silane monomer 3 is joined to the second small inorganic particles 6, the surfaces of the first small particles inorganic 2 will be sufficiently exposed 5. A leaf containing substances to inactivate virus 100 from a third configuration of the present configuration will be described later with reference to Figure 3. Figure 3 is an enlarged view of a cut-out part of leaf 10 containing substances to inactivate virus 100 of the third configuration of the present invention In the leaf containing substances to inactivate virus 100 of the third configuration, the small virus inactivation particles 2 having a virus inactivation capacity are fixed within a leaf body>
    1.
    15 In the configuration of the third configuration, only the small particles of virus inactivation 2 can be retained, or other small inorganic particles 6 and so on that are not small particles of virus inactivation can also be retained, as for example, in the second configuration. Figure 3 shows a representation of an example in which the 20 small particles of virus inactivation 2 and a type of small inorganic particles 6 different from the small particles of virus inactivation 2 are retained. In another possible configuration, two or more types of small inorganic particles can be retained, in addition to the small virus inactivation particles 2.
    25 There is no particular limit imposed on the size of the small virus inactivation particles 2 contained. However, the average particle diameter is preferably 3,000 µm or less. In view of the fact that the small virus inactivating particles 2 can detach from inside the leaf body 1 in some environments of use and with the passage of time, the average particle diameter is particularly preferable from 1 nm to 1,000 µm. The small virus inactivation particles 2 of the third configuration can be retained in the internal space of the sheet 1 by mixing the particles, for example, with a nonwoven produced by interwoven fibers or mixed papers
    B 26/41 produced by mixing cellulose pulp with a binder when the nonwoven or mixed paper and so on is produced as the sheet body 1. Examples of fibers that form the nonwoven include in addition to the fibers 5 synthetic materials described above and natural fibers such as cotton, hemp, and silk, glass, metals, ceramics, cellulose pulp, and
    · Carbon.
    Nonwoven is produced in two stages.
    First, a fuzzy layer referred to as a fluff and used as the base material of the nonwoven h is produced.
    Then the fibers in the pile are joined together, and layers of 10 pile are stacked on top of each other.
    In addition, the small virus inactivation particles 2 of the third configuration can be mixed with the fibers when the fluff is formed or when the fluff layers are stacked.
    When the layers of the fluff are stacked, a layer of fluff containing the small particles of virus inactivation 2 and a layer 15 of fluff containing the small particles of virus inactivation 2 can be stacked.
    Any of the common manufacturing methods, such as the dry consolidation method, the wet method, the continuous filament method, the blown spin method can be used as the method for making the fluff.
    In view of the stability of the small virus 2 inactivation particles, a dry method in which water is not used and heating is not developed is preferably used.
    Any of the common methods, such as thermoconsolidation, a chemical consolidation method, needle method, hydroentanglement method, loop consolidation method, and a steam jet method can be used as the fluff consolidation method .
    An adhesive resin 7 can be mixed to improve the bond strength within the fluff.
    Specific examples of adhesive resin 7 include saturated polyester resins, unsaturated polyester resins, polyvinyl alcohol, polyvinyl acetate, urethane resins, epoxy resins, acrylic resins, alkyd resins, and starch paste.
    When the mixed paper is used as the sheet body 1 of the sheet containing substances to inactivate virus 100 of the third configuration, the mixed paper is obtained by subjecting the cellulose pulp to make the paper. Any pulp, such as cellulose pulp, polyethylene pulp, artificial silk pulp, and vinylon pulp can be used as the pulp above. A single type or combination of a plurality of types of organic synthetic fibers, such as polyester-based fibers, polyurethane-based fibers, polyamide-based fibers, polyvinyl alcohol-based fibers, chloride-based fibers polyvinyl,, polyline-based fibers, and polyacrylonitrile-based fibers can be used in addition to the pulp.
    V When making paper, for example, an appropriate amount of 10 ta reinforcing agent! as glass fibers or crushed fibers it is added to the poIpa for the purpose of ensuring strength as a structural body. The mixture is mixed with water to prepare a diluted slurry, and then the diluted slurry is stirred using a paper machine, such as a paper roll machine. The small virus inactivation particles 2 of the third configuration are added to the unstirred paste and thus bound within the sheet body 1. The virus inactivation leaves of the first to third configurations have been described, but the present invention is not limited to this. Other configurations are, of course, possible. For example, in the first to the second configuration, the 20 small virus inactivation particles 2 are retained on the surface of the leaf body 1, but are not limited to this. The small particles of virus 2 inactivation can be retained on the entire sheet. For example, the small virus inactivating particles 2 can be retained so that they are surrounded by the fibers that make up the sheet 1. It is easy for a person skilled in the art to understand that depending on the material that makes up the sheet body 1 and of the manufacturing method used, the small particles of virus inactivation 2 can be retained not only on the surface of the leaf but also within the leaf, even in the first and second configuration. The present invention will now be described specifically by way of Examples. However, the present invention is not limited to these Examples only. Evaluation of antiviral capacity by the hemagglutination reaction The antiviral capacity of each of the materials (Reference Examples 1 to 27) was evaluated. An influenza virus (influenza A / kitakiusiu / 1 59/93 (H3N2)))
    cultured in MDCK cells was used as a test virus.
    The titration or fraction of mass (HA titration) in the hemagglutination reaction (HA) of the influenza virus that was placed in contact with one of the above materials was determined by the routine method. 5 More specifically, a two-step dilution series of a sample solution that was brought into contact with a suspension of one of the above materials was prepared in a phosphate-saline buffer (PBS), and 50 µL of prepared solutions was added to the wells of the 96-well titration plate made of plastic b.
    Then, 50 µL of 0.5 VOi ° / o of bird erythrocyte suspension was added to each of the wells of the titration pIaca and the wells were left at 4 ° C for 60 minutes.
    Then the erythrocyte sedimentation status was visually observed.
    The HA titration was determined as the maximum dissolution factor of the virus solution in which erythrocyte sedimentation was not found. 15 Sample solutions were obtained as follows.
    First, one of the materials in the Reference Examples shown in Table 1 was placed in the PBS from 10 ° 6 by mass to 1 ° 6 by mass to prepare samples.
    Then 450 µL of influenza virus solution with HA titration of 256 was added to 450 µL of the samples prepared in two different concentrations and the resulting solutions 20 reacted at room temperature for 10 minutes under stirring using a microtube rotator.
    The concentration of the material in each solution was 5 ° /) by mass or 0.5 ° 6 by mass.
    A sample prepared by adding 450 µL of HA virus titration from 256 to 450 µL of PBS and stirring the mixture for 10 minutes using a microtube rotator was used 25 as a control.
    In the present description, the concentration of a suspension means the percentage by mass of a specific component (for example, an iodide or a monovalent copper derivative) based on the total mass (100 ° 6) of the components that make up the suspension including a iodide or a monovalent copper derivative and a solvent.
    Then the solid content was precipitated by means of centrifugation and the supernatant was collected and used as a sample solution.
    The results of the HA titration measurements for each sample solution are shown in Table 2. Table 1
    MANUFACTURER'S FORMULA NUMBER MOLECULAR MATERIAL NAME Example (SUPPLIER) QUALITY Reference 1 Copper sludge (I) Cul WAKO WAKO level 1 2 Silver sludge (I) Agl WAKO CHEMICAL USE 3 Antimony sludge (lll) Sbb Strem chemicals (WAKO) 99.90% 4 iridium sludge (lV) irl ,, Alfa Aesar (WAKO) 99.95 ° 6 5 germanium sludge (lV) Ge | 4 Alfa Aesar (WAKO) 99.999 ° 6 6 germanium sludge (iV) Gel, AIDRICH 99.99 ° 6 7 tin sludge (ll) Sn | 2 Alfa Aesar (WAKO) 99 + ° 6 8 tin sludge (lV) §ii 'Strem chemlcals (WAKO) 95 ° 6 9 sludge of thallium (i) Tll WAKO USE OPTlCO 10 Platinum iodide (ll) PÜ2 Strem chemicals (WAKO) 99 ° 6 11 platinum iodide (lV) Pt | 4 Alfa Aesar (WAKO) 99.95 ° 6 12 palladium lodide ( II) Pdh Strem Chemicals, lnc. 13 bismuth (III) sludge BÜ3 Strem chemicals (WAKO) 99.999% 14 gold loclide (I) Aul Strem chemicals (WAKO) (WAKO) 99 ° 6 15 gold sludge (lll) Aub ChemPUr Feinchemikalien und Forschungsbedarf Gmbh (WAKO) 16 I iron (ll) Fe | 2 Aldrich> 99.99 ° 6 17 Cobalt (ll) iodide with Aldrich 95 ° 6 18 Nih Alfa Aesar nickel iodide (WAKO) 99.50 ° 6 19 zinc iodide ( li) Znk WAKO WAKO level 1 20 mercury lodide (I) Hgl WAKO CHEMICAL USE 21 Indian lodide lnh Alfa Aesar (WAKO) 99,999 ° 6 22 I C copper chloride {I) CuCl WAKO REAGENT DE
    SPECIAL LEVEL 23) Cu8r copper bromide WAKO WAKO 1st. level 24 CuOOCH copper acetate, "TOKYO CHEMICAL INDUSTRY 98 ° 6 REAGENT CO., LTD 25 I Copper (I) CuSCN WAKO CHEMICAL USE 26 Copper (I) Cu, S Alfa Aesar (WAKO) 99.5 ° 6 27 Copper oxide Cu, O WAKO 99.5 + ° 6 NOTE: "WAKO" IN THE TABLE MEANS "WAKO PURE CHEMICAL INDUSTRIES, LTD". Table 2
    TITLE HA FORMULA I MATERIAL CONCENTRATION No. of Example Reference Material Name Mokcular I (PERCENTAGE BY MASS) 5 I 0.5 1 Copper sludge (I) Cul I 8 I 32 to Silver sludge (I) Ag) I 32 I 64 3 Antimony sludge (lil) Sbl, I 16 I 32 4 iridium sludge (lV) lrl, 32 64 5 germanium (lV) sludge Ge | 4 <2 <2 and i germanium (IV) sludge Gel2 <2 2
    7 tin (ll) sludge; Snl, <2 2 8 tin sludge (lV) | Snl '<2 2 9 Thallium iodide (i) Tll 32 64 10 Platinum (Il) iodide Pt | <2 64 11 platinum (lV) iodide Ptl, 32 64 12 Palladium (Il) iodide Pd | 2 "T 64 13 bismuth (lll) iodide Bi | 3 8 64 14 gold (I) Aul 4 64 15 gold iodide (lll) Aub 8 64 16 iron iodide (ll) Feb <2 <2 17 cobalt iodide (ll) cob <2 8 18 nickel iodide Nj12 <2 4 19 zinc iodide (ll) Zn) 2 <2 4 20 Mercury iodide (j) Hgl 32 64 21 klindium indium lnb <2 <2 22 Copper chloride (1) CuCl <2 <2 23 Cu8r copper bromide <2 24 CuOOCH3 copper acetate <2 <2
    25 Copper thiocyanate (1) CuSCN 16 64
    26 Copper sulphide (1) Cu2S 16 64
    27 Cu2O copper oxide 8 64
    LE (SALJNO PHOSPHATE BUFFER) 128
    NOTE 1: "<2" IN THE TABLE REPRESENTS "EQUAL OR LESS THAN THE LOWER LIMIT OF THE HA TITRATION MEASUREMENT" NOTE 2: THE CONTROL TEST HAS BEEN DEVELOPED IN A MATER | AL CONCENTRATION OF 0% (ONLY IN PHOSPHATE BUFFER) -
    s SALINO) As can be seen from the results in Table 2, all materials in Reference Examples 1 through 27 were found to have a virus inactivating effect.
    When the concentration was 5 ° 6, the HA titre was 32 or less, that is, 75 ° 6 or more of the virus was found to be inactive.
    Particularly, for each of the materials including Ge | 4, Ge | 2, Snl2, Snk, Ptl ,, Fe | 2, cok, Ni | 2, ink ,, CuCl, CuBr and CuOOCCH3, a high effect, that is, inactivation 98.44% or more of the virus, which is the lowest measurement limit of the HA titration in this test, was found.
    Preparation of virus inactivation sheets Example 1 A powdered copper (I) iodide in Reference Example 1 was used as the small particles having a virus inactivation capacity.
    Methacryloxypropyltrimethoxysilane (KBM-503, product of Shin-Etsu Chemical Co., Ltd.), which is the silane monomer having an unsaturated bond, was subjected to condensation by dehydration by an effective method to covalently bond the Siian to surfaces of zirconium oxide particles (PCS, 5 product of Nippon Denko -Co., Ltd). and the resulting particles were used as the second small inorganic particles. For this, 40g of iodide. powdered copper (I) and 60g of the second small inorganic particles were pre-dispersed in 900.0 g of ethanol, and these particles were pulverized and
    They are dispersed using a ball mill to obtain a dispersed particle. The average diameter of the dispersed particle obtained was 105 nm. The average particle diameter as used herein is an average particle diameter of the volume. Ethanol was added to the dispersed particle obtained to adjust the concentration of the solid to 1 ° 6 by mass. Tetramethoxysilane (KBM-04, product of Shin-Etsu Chemical Co., Ltd) was added in an amount of 0.3% by mass to obtain the coating solution. Then, an 18 g / m 'artificial silk nonwoven (product from KURARAYKURAFLEX Co., Ltd) was impregnated with the above coating solution and dried to obtain a nonwoven sheet containing substances to inactivate viruses having an effect virus inactivation. 20 Example 2 A polyester monofilament mesh (product of NBC Meshtec lnc.) 305 mesh was dipped in the coating solution prepared in Example
    1. All excess solution was removed and the resulting mesh was dried at 110 ° C for 1 minute. Then the mesh was irradiated with cathode rays at an acceleration voltage of 200 kV and 50 KGy to obtain a mesh sheet containing substances to inactivate viruses having a virus inactivation effect. Example 3 A powdered copper (I) iodide in the Reference Example was used as the small particles having a virus inactivating capacity and was sprayed using a dry spray, Nano jetmizer (product of Aishin Nano Technologies CO., Ltd ). The average particle diameter was 170 nm. SHC900 (a mixture of melamine resin, silicone resin and alkyd resin, a product of Momentive Materials japan LLC) was added to isopropanol so that the amount of solid was 5% by weight.
    Powdered copper (I) iodide by means of the jet mill was added to the prepared mixture (a mixture of SHC900 and isopropanol) in an amount of 1 ° 6 by mass, and the resulting mixture was stirred using a 5 homogenizer prepare a coating solution.
    Then, a non-woven artificial silk (product of KURARAYKURAFLEX CO.,
    . Ltd) of 18 g / m 'was dipped with the above coating solution and dried by hand
    100Â ° C to treat the coating, and a nonwoven sheet containing "substances to inactivate viruses having a virus inactivating effect was thus obtained.
    Example 4 A polyester pellet (product from TORAY industries, lnc.) Having a thickness of 125 µm was hydrophilized by corona treatment and was coated with the coating solution prepared in Example 1 using a 15-bar coating.
    The resulting film was dried at room temperature to obtain a sheet of virus inactivation film having a virus inactivation effect.
    Example 5 Powdered copper (I) iodide by means of the jet mill in Example 3 was added to ethanol in an amount of 2.0% by mass and 20 tetramethoxysilane (KBM-04, product of Shin-Etsu Chemical Co., Ltd.) was added to the mixture (powdered copper (I) iodide and ethanol) in an amount of 0.4 ° C per mass.
    The mixture was pre-dispersed using a homogenizer for 5 minutes to prepare a paste.
    A non-woven artificial silk (product of SHINWA Corp.) of 20 g / m 'was
    25 immersed in the prepared paste.
    All excess pulp was removed, and the nonwoven was dried at 120 ° C for 10 minutes to obtain a sheet of nonwoven containing substances to inactivate viruses having a virus inactivating effect.
    Example 6 A powdered silver (I) iodide in Reference Example 2 was used as the 30 small particles having the virus inactivating ability and was sprayed onto a 140 nm medium diameter particle using a dry spray, Nano jetmizer (product of Aishin Nano Technologies CO., Ltd). The small particles of powdered silver (I) iodide were added to ethanol in a dq 33/41 amount of 4.0 ° 6 per mass, and tetramethoxysilane (KBM-04, product of Shin-Etsu Chemical Co., Ltd.) was added. added to the mixture in an amount of 0.4 ° 6 by mass. The mixture was pre-dispersed using a homogenizer for 5 minutes to prepare a paste. The average particle diameter as used here is an average particle diameter of the volume. After that, a non-woven cotton of 80 g / m 'was dipped in the paste. ready. All excess pulp was removed and the nonwoven was dried at 120 ° C for 10 minutes to obtain a clean sheet having an inactivating effect.
    Viruses. Example 7 A powdered silver (I) iodide in Reference Example 2 was used as small particles having a virus inactivating ability. Methacryloxypropyltrimethoxysilane (KBM-503, product of Shin-Etsu Chemical Co., Ltd), a silane monomer having an unsaturated bond, was subjected to condensation by dehydration by an effective method to covalently bond the silane to the particle surfaces of zirconium oxide (product of Nippon Denko Co., Ltd), and the resulting particles were used as the small inorganic particles except the small virus inactivation particles. 40 g of powdered silver (I) iodide and 60 g of small 20 inorganic particles were pre-dispersed in 900.0 g of methanol, and these particles were pulverized and dispersed using a ball mill to obtain a dispersed particle. The average diameter of the dispersed particle obtained (paste) was 140 nm. Ethanol was added to the paste obtained to adjust the solid concentration to 0.5 ° 6 by mass. The average particle diameter as used here is an average particle diameter of the volume. Then the above paste was applied to an 80 g / m2 artificial silk nonwoven by spraying and the nonwoven was dried to obtain a clean sheet having a virus inactivation effect. -> Example 8 30 A powdered copper (I) thiocyanate in Reference Example 25 was used as small particles having a virus inactivating capacity and was sprayed onto a 120 nm medium diameter particle using a dry spray, Nano jetmizer (product of Aishin Nano Technologies CO.,
    ) to 4
    34/41
    Ltd). The small powdered copper (I) thiocyanate particles were added to ethanol in an amount of 4.0 ° 6 by mass, and tetramethoxysilane (KBM-04, product of Shin-Etsu Chemical Co., Ltd) was added in an amount 2.0% by mass.
    The mixture was pre-
    5 dispersed using a homogenizer for 5 minutes to prepare a paste.
    The average particle diameter as used here is an average diameter of the
    · Volume particle.
    After that, an 80 g / m 'cotton non-woven fabric was dipped in the prepared q paste.
    All excess pulp was removed, and the nonwoven was dried
    10 120 ° C for 10 minutes to obtain a clean sheet having a virus inactivating effect.
    Example 9 A 100.0 g copper (I) thiocyanate powder in Reference Example 25 that was used as the small particles having an inactivation capacity of
    15 viruses were pre-dispersed in 900.0 g of ethanol, and the particles were sprayed and dispersed using a ball mill to obtain a paste having an average diameter particle of 104 nm.
    Then, methacryloxypropyltrimethoxysilane (KBM - 503, product of Shin-Etsu Chemical Co., Ltd), a silane monomer having an unsaturated 2 () bond, was subjected to dehydration condensation by an effective method, to covalently bond silane to the surfaces of the zirconium oxide particles (PCS, product of Nippon Denko Co., Ltd), and the resulting particles were used as the second small inorganic particles.
    Thus, 100 g of second small inorganic particles were
    25 dispersed in the ethanol and were pulverized and dispersed using a ball mill to obtain a paste having an average diameter particle of 20 nm.
    The average diameter of the particle as used here is an average diameter of the volume particle.
    The two types of paste above were added at a mixing rate of 40
    30 ° ') by mass of copper thiocyanate dispersion and 60 ° 6 by mass of dispersion of zirconium oxide particles that were mixed, and ethanol was added to the mixture so that the concentration of the solid was adjusted to 5
    % by mass.
    Then, the resulting paste was applied to an 80 g / m2 artificial silk nonwoven by spraying, and the nonwoven was dried to obtain a clean sheet having a virus inactivation effect. Example 10 5 A powdered copper (I) chloride in Reference Example 22 was used as the small particles having a virus inactivating ability and was. sprayed on a 350 nm medium diameter particle using a dry spray, Nano Jetmizer (product of Aishin Nano Technologies CO.,
    P Ltd). A medium diameter particle as used herein is an average particle diameter of the volume. TL-0511, a SEKISUI FULLER product, used as a reactive hot glue adhesive was ejected in filament form from a HIGH spray gun, manufactured by Nordson K.K, to produce a structural fiber body having adhesive properties. Then the small powdered copper (1) chloride particles were brought into contact with the fiber surfaces of the fiber structural body. The resulting fiber structural body reacted in an environment of 60% humidity and 50 ° C for 4 hours to treat the reactive hot glue adhesive, and a filter was obtained in this way. Example 11 20 A powdered copper (I) chloride in Reference Example 22 was used as the small particles having a virus inactivating capacity and was sprayed onto a 350 nm medium diameter particle using a dry spray, Nano jetmizer (product of Aishin Nano Technologies CO., Ltd). The pulverized copper (I) chloride was added to ethanol in an amount of 0.5 ° 6 per mass, and tetramethoxysilane (KBM-04, product of Shin-Etsu Chemical Co., Ltd) was added in an amount of 0.4 ° 6 by mass. The mixture was pre-dispersed using a homogenizer for 5 minutes to prepare a paste. The average particle diameter as used here is an average particle diameter of the volume. After that, a polyester film (product of TORAY lndustries, lnc.) Having a thickness of 125 µm was hydrophilized by corona treatment and was coated with the coating solution prepared in Example 11 using a bar coater, and the resulting film was dried at 110 ° C for one minute. So the
    %
    The film was irradiated with cathode rays at an acceleration voltage of 200 kV and 50 kGy to obtain a sheet of film containing substances to inactivate viruses having a virus inactivation effect.
    Example 12 5 A powdered copper (I) oxide in Reference Example 27 was used as the small particles having a virus inactivating ability and was
    . sprayed on a medium diameter particle of 460 nm using a dry spray, Nano jetmizer (product of Aishin Nano Technologies CO., 0
    Ltd). The small particles of pulverized copper (I) oxide were added to ethanol in an amount of 4.0 ° 6 per mass, and tetramethoxysilane (KBM-04, product of Shin-Etsu Chemical Co., Ltd) was added in a 0.4 ° 6 by mass.
    The mixture was pre-dispersed using a homogenizer for 5 minutes to prepare a paste.
    The average particle diameter as used here is an average diameter of the volume particle.
    Then, the prepared paste was applied to an 80 g / m 'artificial silk nonwoven per plot, and the nonwoven was dried at 120 ° C to obtain a nonwoven sheet containing substances to inactivate viruses. having a virus inactivating effect. Example 13 100.0 g of a powdered copper (I) oxide was used in Reference Example 27 as small particles having a virus inactivating capacity that was pre-dispersed in 900.0 g of ethanol, and the particles were pulverized and dispersed using a ball mill to obtain a slurry having an average particle diameter of 210 nm.
    Then, methacryloxypropütrimethoxysilane (KBM-503, product of Shin-Etsu Chemical Co., Ltd), a silane monomer having an unsaturated bond, was subjected to condensation by dehydration by an effective method to covalently bond the silane to the surfaces of the zirconium oxide particles 30 (PCS, product of Nippon Denko Co., Ltd.), and the resulting particles were used as the second small inorganic particles.
    100 g of second small inorganic particles were pre-dispersed in ethanol and were pulverized and dispersed using a ball mill to obtain a paste having an average diameter particle of 20 nm.
    The average particle diameter as used here is an average particle diameter of the volume.
    The above prepared pastes were mixed in a mixing range of 5 40 ° 6 by mass of small powdered copper (1) oxide particles and 60 ° C) by mass of zirconium oxide particles, and ethanol was added to the
    - mixing so that the concentration of the solid was adjusted to 5 ° 6 by mass. 0
    After that, a sheet of vinyl chloride wallpaper (dino (registered trademark IO), product of Sumitomo 3M Limited) having a thickness of 200 µm was hydrophilized by corona treatment and then coated with the coating solution prepared in Example 13 using a bar coater, and the resulting sheet was dried at room temperature to obtain a sheet of vinyl chloride containing substances to activate virus having a virus inactivating effect.
    Comparative Example 1 An 18 g / m 'artificial silk nonwoven (product from KURARAYKURAFLEX Co., Ltd.) was used as a nonwoven in Comparative Example 1. Comparative Example 2 20 A nonwoven sheet from the Example Comparative 2 was produced under the same conditions as in Example 1 except that the small particles having a virus inactivating capacity used in Example 1 were not added.
    Comparative Example 3 25 A 305 mesh polyester monofilament mesh (product of NBC Mesgtec lnc.) Was used as a '' mesh sheet from Comparative Example 3. Comparative Example 4 A mesh sheet from Comparative Example 4 was produced under the same conditions as in Example 2 except that the small particles having a virus inactivating capacity used in Example 2 were not added.
    Comparative Example 5
    A nonwoven sheet from Comparative Example 5 was produced under the same conditions as in Example 3 except that the small particles having a virus inactivating capacity used in Example 3 were not added. Comparative Example 6 5 A polyester sheet (product of TORAY lndustries, lnc.) Having a thickness of 125 µm was obtained as a pellet sheet of the Example. Comparative 6. Comparative Example 7
    A sheet of comparative example 7 was produced under the same 10 conditions as in example 4 except that the small particles having a virus inactivating capacity used in example 4 were not added. Comparative Example 8 A non-woven cotton sheet from Comparative Example 8 was produced under the same conditions as in Example 8 except that the small particles having a virus inactivating capacity used in Example 8 were not added. Comparative Example 9 A non-woven sheet of hot glue adhesive from Comparative Example 9 20 was produced under the same conditions as in Example 10 except that the small particles having a virus inactivating capacity used in Example 10 were not added. Comparative Example 10 A sheet of vinyl chloride wallpaper from Comparative example 13 was produced under the same conditions as in the Example. 13 except that the small particles having a virus inactivating ability used in Example 13 were not added. Method of evaluation of antiviral capacity in the present invention In measures of virus inactivation capacity of a leaf containing 30 substances to inactivate virus, an influenza virus (influenza A / kitakiusiu / 1 59/93 (H3N2) cultured in MDCK cells was used as a virus having an envelope, and a feline calicivirus generally used as an alternative to a norovirus was used as a virus that has no envelope.
    .
    Ç b 39/41 When a non-woven sheet or mesh sheet was used as a sheet containing substances to inactivate viruses, a sample (2 cm x 2 cm, four-filament sheet) was placed in a sterile flask. Then, 0.1 mL of a virus solution was added by dropper and left to react at room temperature for 60 minutes. After the reaction for 60 minutes, 1900 µL of a 20mg / mL protein solution was added, and the virus was washed by. pipette. Then, the reaction sample was diluted with a diluted MEM solution up to 10 "'to 10"' (ten-layer serial dilution). 100 µL q of the sample solutions were inoculated into MDCK cells cultured on the titration plate.
    10 After the resulting cells remained for 90 minutes to absorb the virus from inside the cells, 0.7 ° 6 of medium agar was placed in it, and the virus was cultured at 34 ° C in 5% CÕ2 for 48 hours in an incubator. After formalin fixation and methylene blue agitation were developed, the number of plaques formed was counted to record the virus contamination titration (PFU / O.I mL, LogiO) (PFU: plaque forming units). When a sheet of pehcula was used, a sample (5 cm x 5 cm) was placed in a plastic titration sink. Then, 0.1 mL of a virus solution was added by dropper and left to react at room temperature for 60 minutes. The upper surface of the tested sample was covered with a PP (4 cm x 4 cm) sheet to make the contact area between the virus solution and the tested sample uniform during the test. After the reaction for 60 minutes, 1900 µL of a 20mg / mL protein solution was added, and the virus was washed using the pipette. Then the contamination titration (PFU / O.I mL, Log10) (PFU: plaque forming units) was recorded by the plate method. Evaluation of the antiviral capacity of the present invention The antiviral capacity was evaluated for each of Examples 1 to 13 and for Comparative Examples 1 to 10. The results of the evaluation were shown in Tables 3 and 4. The values obtained when a solution of virus 30 was covered with a PP pellet without placing a sample were used as the control values.
    Table 3 tulation of (PFU / O.1mL, Log1O)
    LUENZA CALICIVIRUS FEI EXAMPLE 1 <1 <1 EXAMPLE 2 <1 <1 EXAMPLE 3 <1 "<1 EXAMPLE 5 <1 <1 EXAMPLE 6 <1 <1 EXAMPLE 7 <1 <1 EXAMPLE 8 <1 <1 EXAMPLE 9 <1 <1 EXAMPLE 10 <1 <1 EXAMPLE 12 <1 <1 COMPARATIVE EXAMPLE 1 5.96 5.45 COMPARATIVE EXAMPLE 2 5.64 5.62 COMPARATIVE EXAMPLE 3 5.97 5.60 COMPARATIVE EXAMPLE 4 5.83 5.81 COMPARATIVE EXAMPLE 5 5.70 5.79 COMPARATIVE EXAMPLE 5.6 COMPARATIVE EXAMPLE 5.5 5.4 5.50 CONTROL 6.02 5.95 Table 4 Contamination Mulation (PFU / O.1mL, Log1o) LUENZA) CALJCIVÍRUS FELI <1 <1 EXAMPLE 4 <1 <1 EXAMPLE 11 <1 <1 EXAMPLE 13 COMPARATIVE EXAMPLE 6 6.01 I 5.40 COMPARATIVE EXAMPLE 784 5.84 : 5.90 COMPARATIVE EXAMPLE 10 5.70! 5.76 CONTROL 6.02 I 5.95 As can be seen from the results above, the virus inactivation effect on both viruses was greater in all Examples than in Comparative Examples. The observed effect was very high, that is, the inactivation rate after 60 minutes was 99.9999 ° 6 or higher, so with these leaves, an environment with a laugh Reduced contamination of viruses can be provided. Numerical Reference List 1 leaf body 2 small virus inactivation particle 3 silane monomer or oligomer 4 ligand (reinforcing agent)
    kt 0 ava 5 chemical bond 6 second small inorganic particle 7 adhesive 100 sheet containing substances to inactivate viruses {) q, j¶ 1
    J n · g! l j! j)
    权利要求:
    Claims (15)
    [1]
    1. "SHEET CONTAINING SUBSTANCES TO INACTIVATE VIRUSES" capable of inactivating a virus adhering to it, said leaf containing substances to inactivate viruses characterized by comprising a leaf body, and small 5 particles of monovalent copper derivatives and / or small iodide particles being retained by said sheet body.
    [2]
    . 2. "SHEET CONTAINING SUBSTANCES FOR INACTIVATING VIRUSES" according to claim 1, characterized in that said small particles of 7 monovalent copper derivatives are particles selected from at least one group consisting of a chloride, acetate, sulfide group, iodide, bromide, peroxide, oxide and thiocyanate.
    [3]
    3. "SHEET CONTAINING SUBSTANCES FOR INACTIVATING VIRUSES" according to claim 2, characterized in that said small particles of non-valid copper derivatives are particles selected from at least one group consisting of CuCl, CuOOCCH3, Cul, CuBr, Cu , O, Cu2S, and CuSCN.
    [4]
    4. "SHEET CONTAINING SUBSTANCES TO INACTIVATE VIRUSES" according to any of claims 1, 2 or 3 characterized in that said small particles of iodide are particles selected from at least one group consisting of Cul, Agl, Sb | 3, | r | 4, Geh, Gek, Sn | 2, Snl ,, Tll, Pt | 2, Ptl ,, Pd | 2, Bi | 3, Aul, Au | 3, Fe | 2, Co | 2, Ni | 2, Znl2, Hgl, and | n | 3.
    [5]
    5. "SHEET CONTAINING SUBSTANCES FOR INACTIVATING VIRUSES" according to any of claims 1, 2, 3 or 4, characterized in that said small particles of monovalent copper derivatives and / or said small particles of iodide are retained by said body of sheet through a group of other small inorganic particles that are attached to said sheet body via chemical bonds with a silane monomer and / or a polymerization product of said silane monomer.
    [6]
    6. "SHEET" characterized by using said sheet containing substances to inactivate viruses according to any claim 1, 2, 3, 4 or 5.!
    [7]
    7. "PROTECTION CLOTHING" characterized by using said sheet containing substances to inactivate viruses according to any claim 1, 2, 3, 4 or 5,
    ^ K 2/2
    [8]
    8. "GLOVE" characterized by using said sheet containing substances to inactivate viruses according to any claim 1, 2, 3, 4 or 5.
    [9]
    9. "MEDICAL USE TYPE" characterized by using said sheet containing substances to inactivate viruses according to any claim 5 1, 2, 3, 4 or 5.
    [10]
    10. "CAPA" characterized by using said leaf containing substances to inactivate viruses according to any claim 1, 2, 3, 4 or 5.
    [11]
    11. "SHOE PROTECTOR" characterized by using said sheet containing substances to inactivate viruses according to any claim 1, 2, 3, 4 10 or 5.
    [12]
    12. "FILTER" characterized by using said sheet containing substances to inactivate viruses according to any claim 1, 2, 3, 4 or 5.
    [13]
    13. "SURGICAL TAPE" characterized by using said sheet containing substances to inactivate viruses according to any of claims 1, 2, 3, 4 15 or 5.
    [14]
    14. "GAZE" characterized by using said sheet containing substances to inactivate viruses according to any claim 1, 2, 3, 4 or 5.
    [15]
    15. "WALLPAPER" characterized by using said sheet containing substances to inactivate viruses according to any claim 1, 2, 3, 4 20 or 5.
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    同族专利:
    公开号 | 公开日
    AU2010302092B2|2014-11-06|
    JPWO2011040048A1|2013-02-21|
    US9155309B2|2015-10-13|
    EP2484368A1|2012-08-08|
    EP2484368B1|2018-01-03|
    RU2550922C2|2015-05-20|
    CN102548563A|2012-07-04|
    KR20120086301A|2012-08-02|
    JP5577346B2|2014-08-20|
    CA2776363A1|2011-04-07|
    WO2011040048A1|2011-04-07|
    EP2484368A4|2013-12-04|
    KR101759363B1|2017-07-18|
    CA2974025A1|2011-04-07|
    IN2012DN02363A|2015-08-21|
    RU2012115649A|2013-11-10|
    AU2010302092A1|2012-04-12|
    CA2776363C|2019-02-19|
    US20120171276A1|2012-07-05|
    CA2974025C|2019-08-20|
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    法律状态:
    2020-08-25| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2020-09-15| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2020-10-20| B08F| Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]|Free format text: REFERENTE A 10A ANUIDADE. |
    2021-01-05| B11B| Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements|
    2021-11-03| B350| Update of information on the portal [chapter 15.35 patent gazette]|
    优先权:
    申请号 | 申请日 | 专利标题
    JP2009-230946|2009-10-02|
    JP2009230946|2009-10-02|
    PCT/JP2010/005931|WO2011040048A1|2009-10-02|2010-10-04|Virus inactivation sheet|
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